Earth-abundant transition-metal catalysis & application of novel, solid higher-order zincates

We are currently developing different (asymmetric) approaches towards the synthesis of biaryls via Ni/N,N-ligand catalyzed Negishi cross-coupling reaction. 

In the recent past, this approach has already been adapted in the development of an atroposelective variant of the former Negishi cross-coupling reaction. Beside its discovery and development, we are currently still working on examination of the underlying reaction mechanism of this particular cross-coupling reaction, since it might also important to other earth-abundant transition-metal catalyzed cross-coupling reactions especially emplyoing zinc reagents. In this context, we are also interested in the application of this methodolgy in the total synthesis of biarylic natural products.