Publications
Independent career
S. Strey, K. Olbricht, D. Sommer, D. Berthold, Reductive homo-coupling of electrophiles towards symmetric biaryls via photo-redox and Nickel catalysis ChemRxiv 2025. DOI: 10.26434/chemrxiv-2025-dpw0x.
D. Groß, L. Kirchhoff, B. Schiller, L. Bucher, O. Trapp, D. Berthold, Application of Solid Higher-Order Zincates Enables a Ni/Lassaletta-Ligand-Catalyzed, Atroposelective Negishi Cross-Coupling Reaction J. Am. Chem. Soc. 2025, 147, 29852-29863. DOI: 10.1021/jacs.5c06296.
highlighted in Synfacts: Solid Higher-Order Zincates for Atroposelective Solid Higher-Order Zincates for Atroposelective Cross-Coupling
N. J. Kurrle, C. J. B. Seifert, N. Hampel, T. Rauch, M. Thoma, L. V. Parziale, M. S. R. Ebeling, D. Berthold, O. Trapp, Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration ChemBioChem 2025, 26, e202500395. DOI: 10.1002/cbic.202500395.
M.-C. Materis, W. A. L. van Otterlo, D. Berthold, Concise Access to Naphthalene Building Blocks for Naphthylisoquinoline Alkaloid Synthesis via Transition-Metal Catalysis ChemCatChem 2024, e202401070. DOI: 10.1002/CCTC.202401070.
D. Groß, W. van Otterlo, O. Trapp, D. Berthold, Atroposelective Ni(II)-Catalyzed Cross-Coupling Reactions Enable a Deeper Understanding of Negishi Couplings: Isolation and Application of Solid Aryl Higher-Order Zincates Chem. Eur. J. 2023, e202302841. DOI: 10.1002/chem.202302841.
Post-Doc
M. G. Raab, O Trapp, D. Berthold, RaabPhos, an Air-Stable, Highly Active Ferrocenyl Phosphasilinane Ligand, for Palladium-Catalyzed C–C and C–N Bond-Forming Cross-Coupling Reactions Org. Lett. 2025, accepted article. DOI: 10.1021/acs.orglett.5c03832.
C. Kremser, C. A. Lauer, L. Kober, D. Berthold, O. Trapp, Synthesis of Biaryl-Based Phosphasilinanes via Giese-Type Addition for Palladium-Catalyzed Cross-Coupling Reactions J. Org. Chem. 2025, 90, 8347-8352. DOI: 10.1021/acs.joc.5c00917.
M. T. Daiger, S. Giofré, D. Berthold, B. Breit, Rhodium-Catalyzed Enantioselective Intramolecular Hydroalkoxylation of Allenes and Application in the Total Synthesis of (R,R,R)-alpha-Tocopherol Chem. Eur. J. 2024, 30, e20242010. DOI: 10.1002/chem.202402010.
S. B. Wagh, D. Berthold, Majeed, L. K. Lewis, D. Schilter, B. Mertens, A. Evidente, W. A. L. van Otterlo, V. Mathieu, A. Kornienko, Sphaeropsidin A C15–C16 Cross-Metathesis Analogues with Potent Anticancer Activity ChemMedChem 2024, 19, e202400288. DOI: 10.1002/cmdc.202400288.
D. Berthold, W. van Otterlo, Unprecedented direct asymmetric total syntheses of 5,8’-naphthylisoquinoline alkaloids from their fully substituted precursors employing a novel Nickel/N,N-ligand-catalyzed atroposelective cross-coupling Chem. Eur. J. 2023, e202302070. DOI: 10.1002/chem.202302070.
A. Haydl, A. Geissler, D. Berthold, Comprehensive Organometallic Chemistry IV. Eds. G. Parkin, K. Meyer, D. O’hare. Amsterdam: Elsevier, 2022, chapter 12.08: Metal-Catalyzed Amination: C–N Bond Formation. DOI: 10.1016/B978-0-12-820206-7.00119-0
D. Berthold, A. M. Haydl, J. C. Leung, U. Scholz, Q. Xiao, Z. Zhu, Synthesis of arylamines in the light of their application in the chemical and pharmaceutical industry. Methodologies in Amine Synthesis. Eds. A. Ricci and L. Bernardi. Weinheim: Wiley-VCH, 2021, chapter 10. DOI: 10.1002/9783527826186.ch10
Undergraduate
D. Berthold, B. Breit, Synthesis of (–)-(R)-Sitagliptin by Rh(I)-catalyzed Asymmetric Hydroamination Eur. J. Org. Chem. 2021, 46, 6247-6249. – In Memory of Klaus Hafner. DOI: 10.1002/ejoc.202100832.
D. Berthold, B. Breit, Total Syntheses of Cylindrocyclophanes Exemplifying the Power of Transition-Metal Catalysis in Natural-Product Synthesis Synlett 2020, The Power of Transition Metals: An Unending Well-Spring of New Reactivity, A-K. DOI: 10.1055/s-0040-1707144.
D. Berthold, B. Breit, Asymmetric Total Syntheses of (–)-Angustureine and (+)-Cuspareine via Rhodium-Catalyzed Hydroamination Org. Lett. 2019, 22, 565-568. DOI: 10.1021/acs.orglett.9b04334.
D. Berthold, J. Klett, B. Breit, Rhodium-Catalyzed Asymmetric Intramolecular Hydroarylation of Allenes: Access to Functionalized Benzocycles Chem. Sci. 2019, 10, 10048-10052. DOI: 10.1039/C9SC03894A.
D. Berthold, A. G. A. Geissler, S. Giofré, B. Breit, Rhodium-catalyzed Asymmetric Intramolecular Hydroamination of Allenes Angew. Chem. Int. Ed. 2019, 58, 9994-9997. DOI: 10.1002/anie.201904833.
D. Berthold, B. Breit, Total Synthesis of (–)-Cylindrocyclophane F: A Yardstick for Probing New Catalytic C–C Bond-Forming Methodologies Chem. Eur. J. 2018, 24, 16770-16773. DOI: 10.1002/chem.201804585.
D. Berthold, B. Breit, Chemo-, Regio- and Enantioselective Rhodium-Catalyzed Allylation of Triazoles with Internal Alkynes and Terminal Allenes Org. Lett. 2018, 20, 598-601. DOI: 10.1021/acs.orglett.7b03708.
A. M. Haydl, D. Berthold, P. A. Spreider, B. Breit, Stereodivergent and Protecting-Group-Free Synthesis of the Helicascolide Family: A Rhodium-Catalyzed Atom-Economical Lactonization Strategy Angew. Chem. Int. Ed. 2016, 55, 5765-5769. DOI: 10.1002/anie.201600632.